Comparative studies of gamma-interferon receptor-like proteins of variola major and variola minor viruses
نویسندگان
چکیده
منابع مشابه
Hybrids Derived from the Viruses of Variola Major and Cowpox.
The isolation of presumptive hybrids from the viruses of variola major and cowpox has already been described (Dumbell & Bedson, 1964). We report here the detailed characterization of the 16 clones of virus obtained. As with the alastrimrabbit pox hybrids considered in the previous paper (Bedson & Dumbell, 1964), attention has been paid to the behaviour of the ceiling temperature character in re...
متن کاملIndependent evolution of monkeypox and variola viruses.
Smallpox was eradicated more than 10 years ago, but infection with another Orthopoxvirus, monkeypox virus, can result in a clinical picture resembling smallpox. Human infection with monkeypox virus is extremely rare, not easily transmitted, and confined to the rain forest belt of Africa (Z. Jezek and F. Fenner, p. 81-102, in Human Monkeypox, 1988). Evidence that variola virus, the causative age...
متن کاملThe highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon
Variola virus (VARV) caused smallpox, one of the most devastating human diseases and the first to be eradicated, but its deliberate release represents a dangerous threat. Virulent orthopoxviruses infecting humans, such as monkeypox virus (MPXV), could fill the niche left by smallpox eradication and the cessation of vaccination. However, immunomodulatory activities and virulence determinants of ...
متن کاملRemaining Questions about Clinical Variola Major
After the recent summary of World Health Organization-authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the cause of the high mortality rate among pregnant women and whether ocular smallpox is partly the result of trachoma or vitamin A deficiency. The joi...
متن کاملJoint Diseases Following Variola
One day in last October I was hurriedly called to see a European child, who was suffering from fever and had a convulsion an hour previously. Three days after characteristic variolar eruptions appeared on the wrist and forehead. The small-pox gradually extended and became confluent. Two days after a younger brother of the child got fever and afterwards small-pox. On the 9th day of his illness t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1996
ISSN: 0014-5793
DOI: 10.1016/0014-5793(96)00069-5